Manchester United winger Ashley Young has been ruled out for two to three weeks while Phil Jones "doesn't look great" after the England duo sustained injuries during the 5-0 win at Fulham.
Young was hurt while tackling Dickson Etuhu, picking up an unspecified injury that Sir Alex Ferguson has revealed will sideline him until January and Jones damaged his jaw after being elbowed by Clint Dempsey while competing for the ball in mid-air, but Ferguson did not give an estimate for his time in the treatment room.
"The tackle on Ashley Young was a very aggressive tackle and I will have to see that again," Ferguson told MUTV. "Fulham were very aggressive in the second half and Ashley Young has paid the price for that. He has got a sore one so will be out for two to three weeks."
He added: "On Phil Jones it was an elbow from Dempsey, but I don't think it was intentional. But he caught him with an elbow.
"We are sending him for an X-ray tomorrow and it doesn't look great. We are picking up injuries at the moment."
Ferguson revealed that Rio Ferdinand was omitted from the starting line-up for tonight's 5-0 Barclays Premier League victory at Craven Cottage because of a foot injury.
The England defender will miss the clash with Wigan on Boxing Day, but should return in time to face Blackburn on New Year's Eve.
"Rio got a knock on the foot against QPR. I think he will be available for Blackburn, not Wigan," said Ferguson.
Danny Welbeck, Nani and Ryan Giggs were on target in a first half that was dominated by United, with Wayne Rooney and Dimitar Berbatov completing the rout after the interval.
"We played some superb football in the first half," said Ferguson. "It's not an easy place to come. We have experienced that in the last three years. We have got one point from nine here so that shows you the difficulties. But the players were really on song and just continued their form from a great display against QPR."